|
KMID : 0978920120130010006
|
|
Korean Journal of Clinical Geriatrics
2012 Volume.13 No. 1 p.6 ~ p.6
|
|
|
The Leukocyte Telomere Length is Independently Associated with Physical Function in Elderly Women
|
|
Lee Jee-Yon
Kim Jung-Ha
Bang Hyo-Weon
Ko Jae-Hong
Lee Duk-Chul
|
|
|
Abstract
|
|
|
Background: It has been reported that declined physical function has close relationship with age-related disease and high mortality in older people. Since telomere length reflect of aging, physical function and telomere length may have
relationships. However results of previous studies were inconsistent. Therefore the purpose of this study was to investigate the relationship between physical function and telomere length in elderly women.
Methods:,/b> A total of 117 elderly women were included. We measured physical function by using physical performance score as the sum of walking speed score, chair stand score and tandem standing score. The leukocyte telomere length was measured using quantitative real-time PCR method.
Results: Physical performance score was negatively correlated with age (r=-0.42, p＜0.01), telomere length (r=0.28, p=0.002), waist circumference (r=-0.23, p=0.01), body fat (r=-0.19, p=0.04), triglyceride (r=-0.20, p=0.03), geriatric depression scale-15 scores (r=-0.27, p＜0.01 and positively correlated with Korean mini-mental state examination (r=0.20, p=0.03) and lean/fat mass (r=0.25,p=0.01). With a stepwise multiple regression analysis, telomere length was found to be an independent factor associated with physical performance score after adjustment for confounding variables.
Conclusions: This study suggests physical function is associated with telomere length in elderly women. Further
studies are warranted to elucidate the precise mechanism of this association.
|
|
|
KEYWORD
|
|
|
Telomere length, Physical function, Elderly women
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|